Vaporized Hydrogen Peroxide (VHP) Decontamination

As a leader in GMP Cleaning in New England, Nx2 Services offers VHP decontamination. Vaporized Hydrogen Peroxide decontamination is a process where hydrogen peroxide is vaporized and the vapor circulates throughout the space to provide a fully decontaminated environment. The thin layer of hydrogen peroxide within the environment will reach a saturation point, or dew point that that forms a condensate over all surfaces which kills micro-organisms.

This process produces a 6-log reduction when complete.

Applications:

-Bioprocessing, biomanufacturing and production zones.

-Biosafety labs of all levels

-Cleanrooms and research labs

-Post-construction and commissioning of new suites

-Shutdown and end of campaign facility restarts

-Emergency response

-Equipment bio-decontamination

VHP Process

Safety

VHP produces a residue free byproduct that does not require any wiping or cleaning after the process is complete.

The dry sterilization process leaves behind only oxygen and hydrogen.

Using a vapor process and not a wet process reduces the risk of condensation, preventing damage to electronics, surfaces, optics, and HEPA filters.

Efficacy

The VHP process is proven effective against a wide range of microorganisms, including fungi, spores, bacteria, DNA and RNA.

Chemical and biological indicators are placed through the environment to validate efficacy of the process. Biological indicators are cultured to ensure efficacy.

VHP produces a six-log reduction in the treated environment.

Nx2 utilizes high-grade 30-35% aqueous hydrogen peroxide solution. All products used have an RFID label for traceability and auditing.

Large, complex spaces are optimal for VHP decontamination. Nx2 performs site evaluations, method statements, and risk assessments prior to performing decontamination. Chemical and biological indicators ensure that all surfaces were treated.

Routine or Emergency Services

VHP decontamination has become a go-to solution for GMP and laboratory facilities who operate within strict environmental limits.

When an incursion occurs and facilities require full decontamination to resume operations, this is the final step.

VHP cleaning has also been incorporated into regular maintenance programs, introducing a different chemistry to ensure operations are not sidelined due to an incursion.

Nx2 provides regular routine remediation, as well as emergency remediation.

Ensure manufacturing downtime is eliminated by introducing VHP process to your GMP maintenance.

The entire process is documented for auditing purposes, from site survey, to bio-decontamination reporting.

Response Time

Being a local company, our response time to customers is reduced from weeks to days.

Once established as a customer, Nx2 often provides same day service to our customers for emergency services; from power outages that result in the need for requalification cleaning to water intrusion events that require water mitigation, as well as recertification cleaning.

VHP cleaning is an effective way to decontaminate all of the places that manual cleaning can not reach.

Equipment Decontamination

VPH is the most effective process for decontaminating equipment

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Incubators, Bio-safety Cabinets

As campaigns turnover, or an incursion happens, Nx2 can provide BSC, LFH/Fume hood decontamination.

VPH is circulated through a closed loop system to decontaminate all portions of the enclosure. PPM is monitored through the process to ensure efficacy.

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Pass Throughs & Material Airlocks

Easily decontaminate these areas of a space that are prone to contamination. Stop an incursion by setting up regular decontamination of the areas that are most common exposure risks.

Cage/Rack Washers & Freeze Dryers

Freeze dryers, refrigerators and washers are often not part of a regular cleaning program and can harbor contaminants. Often the surfaces inside are not easily cleaned by manual wiping due to many small parts and their complexity.

Regular decontaminations can allow a manufacturing facilities to incur less downtime by proper decontamination of these areas that are often exposed to potential contaminates.

Nx2 Approach

VHP is an effective addition to a comprehensive contamination control program. Along with regular manual cleaning, adding in another set of chemistry on a monthly, quarterly or semi-annual basis allows a full reset of your GMP facility.

Prior to a VHP decontamination, Nx2 personnel perform a through inspection and/or cleaning service to remove any visible soiling that may prevent the VHP from performing its decontamination. Eliminating any dust or soiling ensures that all surfaces are thoroughly treated by the vapor.